The Causes of Knee Pain and How It Is Treated

5 March 2025  ·  Dr. Ion Bogdan Codorean

The Causes of Knee Pain and How It Is Treated
Knee pain is a widespread condition that can affect people of any age and can be caused by a number of factors. It can appear either as a result of acute trauma or of an underlying medical condition. Knee pain is usually disabling, seriously affecting a person's quality of life. Because the knee plays a central role in everyday mobility, any dysfunction of this joint has the potential to become an obstacle to movement and to prevent day-to-day activity. It is therefore extremely important to identify correctly the factors causing knee pain, as well as those that contribute to providing appropriate treatment. The aim of this article is to give a brief account of the anatomy of the knee, the general causes of knee pain, the underlying medical conditions, risk factors, typical symptoms, diagnostic examinations, the therapies available and ways of preventing pain. The anatomy of the knee The knee is one of the most complicated joints in the human body, responsible for overall mobility and balance during physical movement. The joint lies between the femur, the tibia and the kneecap. While most joints in the body allow limited movement, the knee supports flexion and extension as well as limited rotation of the tibia. To truly understand the complexity of the knee, however, we need to talk about its basic structures. The bones are held in place by ligaments, which are elastic tissues that stabilise the joint. Some of the key ligaments of the knee are the collateral ligaments (medial and lateral), which stabilise the knee at the sides, and the cruciate ligaments (anterior and posterior), which control the rotation and gliding of the femur on the tibia. Articular cartilage — the protective covering of the bone surfaces and the material that cushions friction — is necessary for the knee to function normally and without pain. Two crescent-shaped segments of cartilage called the menisci act as cushions, protecting the bones from impact and distributing pressure evenly through the joint. The muscles and tendons around the knee help it move. The patellar tendon, for example, connects the kneecap to the tibia, and the hamstring muscles stabilise the knee during walking and other movements. It is vital that all these structures work together in harmony to keep the knee healthy and mobile. The causes of knee pain Pain can have a variety of causes, such as:
  • Acute injuries: A sudden movement or trauma can cause injury to the knee. Sudden trauma can result in damage to the ligaments or the meniscus, dislocations or contusions.
  • Overuse: Physical activities that stress the knee, such as long-distance running, climbing stairs or playing impact sports, can lead to overloading of the joint. Excessive strain can cause inflammation of the tendons or bursae, which can cause pain.
  • Malalignment of the knee: Alignment problems, such as a displaced kneecap, can lead to inappropriate friction between the bones. Malalignment can cause continuous pain, particularly during activities that involve bending or straightening the knee.
  • Repetitive strain: Repetitive knee movements, such as lifting weights, squatting or twisting, can lead to inflammation of the tendons, causing pain and stiffness.
  • Obesity: Excess weight puts pressure on the knees, and this can lead to premature wear of the cartilage and to chronic pain. People who are overweight are susceptible to developing injuries or conditions involving the knee joints.
  • A lack of vitamins or minerals: A poor intake of essential nutrients, including vitamin D, calcium and magnesium, can adversely affect the health of bones and joints. Vitamin and mineral deficiency can affect joint structures and the body's natural healing time.
  • Age: With advancing age, the joints weaken and become more prone to degeneration and wear.

The conditions that cause knee pain

The conditions that cause knee pain Knee pain can be caused by a variety of medical conditions affecting the joint. Some of the most common causes are:
  • Osteoarthritis: This is one of the major causes of persistent knee pain. Although osteoarthritis is usually associated with ageing, it can also be caused by a previous injury.
  • Rheumatoid arthritis: Unlike osteoarthritis, rheumatoid arthritis is an autoimmune condition in which the immune system mistakenly attacks healthy joint tissue. This condition causes severe inflammation, stiffness and persistent pain in the knee. Rheumatoid arthritis can also be experienced in other joints throughout the body.
  • Ligament injuries: These occur frequently in people who play sports involving sudden changes of direction or rapid movements. A ligament tear can be very painful and can lead to instability, with surgery generally being necessary to allow the joint to function normally.
  • Meniscal injuries: The menisci are cartilage cushions whose role is to absorb shock and distribute weight between the bones. They can be injured by direct blows or sudden changes in movement. The symptoms of these injuries usually include pain, local swelling and stiffness.
  • Patellar tendinitis: Patellar tendinitis is inflammation of the tendon connecting the kneecap to the tibia. It can be caused by repeated stress on the knee, usually in athletes who take part in high-impact sports such as football, basketball or volleyball.
  • Bursitis: Bursitis is inflammation of the bursae, small fluid-filled sacs whose role is to minimise friction between bones and soft tissues. In the knee, bursitis can arise as a consequence of repetitive pressure or direct trauma.
  • Patellofemoral syndrome: This arises from trauma to the kneecap and manifests as the kneecap rubbing directly against the femur. Patients with this syndrome often feel pain at the front of the knee. The discomfort can be aggravated by activities requiring the legs to bend, such as running or climbing stairs.

Risk factors

There are various reasons that can make a person susceptible to knee pain. They are as follows:
  • Age: Degeneration of the joints and cartilage is a natural process that can lead to osteoarthritis.
  • Body weight: Obesity and being overweight place excessive pressure on the knee joints, and so there could be premature degeneration of the joints.
  • Physical activity: People who play sports with repetitive impact are at increased risk of injury.
  • Family history: Certain conditions, such as arthritis, can be inherited genetically.
The symptoms of knee pain The signs of knee pain also differ depending on the cause. They can be:
  • Chronic or intermittent pain;
  • Local swelling;
  • Stiffness and an inability to bend or straighten the knee;
  • Creaking or popping sounds during movement;
  • A feeling of weakness in the knee joint.

Diagnosing knee pain

Diagnosing knee pain To diagnose the cause of the pain accurately, the doctor may carry out a full physical examination, which may include imaging studies such as X-rays, MRI or ultrasound. Based on the patient's history and symptoms, additional tests may be needed, such as blood tests, to identify the cause of the problem. Treating knee pain The treatment of knee pain depends on the severity of the condition and on its underlying cause. The treatment plan may include:
  • Non-steroidal anti-inflammatory drugs (NSAIDs) aimed at relieving inflammation and discomfort;
  • Physiotherapy designed to strengthen the muscles around the knee and increase mobility;
  • Corticosteroid injections to ease significant inflammation;
  • Surgery to repair torn ligaments, replace the knee joint or correct other structural abnormalities.

Preventing knee pain

Knee pain is a problem commonly encountered by most people, but one that can be prevented or treated appropriately. Determining why the pain appears — whether it is a degenerative condition, an acute condition or an autoimmune one — is the most important step towards a successful recovery. Given the complicated anatomy of the knee, prevention is important for the overall long-term functioning of the joint. If you are dealing with chronic pain, it is advisable to consult a specialist who will give you a diagnosis and a sound treatment programme. Article sources: Mayo Clinic, M.C. Knee pain. Available at https://www.mayoclinic.org/diseases-conditions/knee-pain/symptoms-causes/syc-20350849 Johns Hopkins Medicine, J.H.M. Knee Pain and Problems. Available at https://www.hopkinsmedicine.org/health/conditions-and-diseases/knee-pain-and-problems Cleveland Clinic, C.C. Knee pain. Available at https://my.clevelandclinic.org/health/symptoms/21207-knee-pain National Health Service, N.H.S. Knee pain. Available at https://www.nhs.uk/conditions/knee-pain/
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Dr. Ion Bogdan Codorean
About the author

Dr. Ion Bogdan Codorean

Consultant in Orthopaedics and Traumatology · Doctor of Medicine

A specialist with over 20 years of experience in arthroscopic surgery, sports traumatology and complex ligament reconstruction. Founder of the Artro Sport Clinic in Bucharest.

ArthroscopyLigamentsMeniscusShoulderSports Traumatology
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